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Prognostic significance of ASXL1 mutations in acute myeloid leukemia: A systematic review and meta-analysis
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Maryam Sheikhi    , Mehrdad Rostami , Gordon Ferns , Hossein Ayatollahi , Payam Siyadat , Yasamin Ayatollahi , Zahra Khoshnegah |
| Department of Laboratory Hematology and Blood Banking, Faculty of Allied Medicine, Kerman University of Medical Sciences, Kerman, Iran , zkhoshnegah@gmail.com |
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Abstract: (524 Views) |
Background: Although genetic mutations in additional sex-combs-like 1 (ASXL1) are prevalent in acute myeloid leukemia (AML), their exact impact on the AML prognosis remains uncertain. Hence, the present article was carried out to explore the prognostic importance of ASXL1 mutations in AML.
Methods: We thoroughly searched electronic scientific databases to find eligible papers. Twenty-seven studies with an overall number of 8,953 participants were selected for the current systematic review. The hazard ratio (HR) and 95% confidence interval (CI) for overall survival (OS), event-free survival (EFS), and relapse-free survival (RFS) were extracted from all studies with multivariate or univariate analysis. Pooled HRs and p-values were also calculated as a part of our work.
Results: The pooled HR for OS in multivariable analysis indicated that ASXL1 significantly diminished survival in AML patients (pooled HR: 1.67; 95% CI: 1.342-2.091).
Conclusions: ASXL1 mutations may confer a poor prognosis in AML. Hence, they may be regarded as potential prognostic factors. However, more detailed studies with different ASXL1 mutations are suggested to shed light on this issue.
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| Keywords: Acute myeloid leukemia, Prognosis, Additional sex comb-like 1, ASXL1, ASXL1 mutation. |
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Full-Text [PDF 1040 kb]
(213 Downloads)
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Type of Study: Review Article |
Subject:
Hematology
Received: 2022/05/2 | Accepted: 2023/02/26 | Published: 2024/02/21
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